AHK-Cu Research Guide: Copper Tripeptide in Hair Follicle Studies
AHK-Cu is a copper-binding tripeptide most-studied for its effects on dermal papilla cells and follicular angiogenesis.
What is AHK-Cu?
AHK-Cu is a copper (II) complex of the tripeptide Ala-His-Lys. The peptide's histidine residue coordinates copper with high affinity, producing a stable blue-violet complex frequently used in dermatological and follicular research.
Mechanism of action
In cultured dermal papilla cells, AHK-Cu has been shown to upregulate VEGF expression, extending the anagen (growth) phase of the hair follicle cycle and promoting perifollicular vascularization.
Additional reported effects include modulation of TGF-β signaling and antioxidant support via copper-dependent superoxide dismutase pathways.
Sourcing & purity
Research-grade material should be ≥99% pure by HPLC with peptide content confirmed via mass spectrometry. Redline Bio material ships with batch documentation; independent third-party COAs are published on the lab reports page as testing returns.
Compliance reminder
Sold and distributed for laboratory research use only. Not approved by the FDA for human consumption, diagnosis, treatment, or cure of any disease. Researchers are responsible for compliance with all applicable institutional, state, and federal regulations.
Frequently asked questions
What is AHK-Cu?
AHK-Cu is a tripeptide (Ala-His-Lys) that binds a copper (II) ion with high affinity. It is a structural cousin of the more familiar GHK-Cu, but with a distinct research profile focused on hair-follicle biology.
How is AHK-Cu different from GHK-Cu?
Both are copper-binding peptides that modulate wound-healing and angiogenic pathways. GHK-Cu is broadly studied in skin remodeling; AHK-Cu has stronger literature specifically in hair follicle dermal papilla cell proliferation and follicular VEGF expression.