ARA-290 (Cibinetide) Research Guide: Innate Repair Receptor Peptide
ARA-290 is an 11-residue peptide derived from erythropoietin's B-helix that engages the innate repair receptor (IRR) — an EPO-receptor / βcR heterodimer — without erythropoietic activity.
What is ARA-290?
ARA-290 (Cibinetide) is a peptidomimetic of the B-helix of human erythropoietin, developed to isolate EPO's tissue-protective activity from its hematopoietic activity.
Mechanism of action
The peptide binds the innate repair receptor (IRR) — a heterodimer of EPO-R and the common β-chain (CD131) — expressed on injured cells. IRR activation drives anti-apoptotic, anti-inflammatory, and reparative signaling cascades. ARA-290 does not engage the EPO homodimer required for erythropoiesis.
Sourcing & purity
Research-grade material should be ≥99% pure by HPLC with peptide content confirmed via mass spectrometry. Redline Bio material ships with batch documentation; independent third-party COAs are published on the lab reports page as testing returns.
Compliance reminder
Sold and distributed for laboratory research use only. Not approved by the FDA for human consumption, diagnosis, treatment, or cure of any disease. Researchers are responsible for compliance with all applicable institutional, state, and federal regulations.
Frequently asked questions
What is ARA-290?
ARA-290 (Cibinetide) is an 11-amino-acid pyroglutamate helix-B peptide derived from the B-helix of erythropoietin. It selectively engages the innate repair receptor (a heterodimer of EPO-R and the common β-chain / CD131) without activating the classical EPO homodimer.
Why does that matter?
Full-length EPO drives both tissue-protective and erythropoietic effects. ARA-290 retains only the tissue-protective arm, allowing sustained exposure in study models without polycythemia — the basis for its neuropathy and tissue-protection research profile.
Published data?
Clinical research has explored ARA-290 in small-fiber neuropathy (including sarcoidosis-associated), diabetic neuropathy, and post-surgical repair models.