KPV Research Guide: α-MSH Tripeptide in Inflammation Studies
KPV is the C-terminal tripeptide of α-melanocyte stimulating hormone — a compact anti-inflammatory sequence widely studied in gut mucosal research.
What is KPV?
KPV is the shortest bioactive fragment of α-melanocyte stimulating hormone (α-MSH), consisting of just three amino acids: Lys-Pro-Val. Despite its small size it retains most of the anti-inflammatory activity of the full 13-residue parent peptide.
Mechanism of action
KPV is transported into cells via the intestinal oligopeptide transporter PepT1, where it directly modulates NF-κB nuclear translocation. Published cell culture and rodent colitis studies show reductions in TNF-α, IL-1β, IL-6, and iNOS expression.
The peptide is also studied topically for mast-cell stabilization in dermatologic inflammation models.
Sourcing & purity
Research-grade material should be ≥99% pure by HPLC with peptide content confirmed via mass spectrometry. Redline Bio material ships with batch documentation; independent third-party COAs are published on the lab reports page as testing returns.
Compliance reminder
Sold and distributed for laboratory research use only. Not approved by the FDA for human consumption, diagnosis, treatment, or cure of any disease. Researchers are responsible for compliance with all applicable institutional, state, and federal regulations.
Frequently asked questions
What is KPV?
KPV is a tripeptide consisting of Lysine-Proline-Valine — the C-terminal three residues of α-MSH. It is studied for its ability to reproduce the anti-inflammatory effects of the parent hormone at a fraction of the molecular size.
Mechanism?
Published work shows KPV modulates NF-κB signaling, reduces pro-inflammatory cytokine release (TNF-α, IL-1β, IL-6), and downregulates iNOS in intestinal epithelial cell models. It appears to enter cells via the PepT1 oligopeptide transporter.
Common research uses?
KPV is most commonly studied in models of inflammatory bowel disease (colitis), atopic dermatitis, and mast-cell activation.