MOTS-C Research Guide: Mitochondrial Peptide, Metabolism & Half-Life
MOTS-C is a 16-amino-acid peptide encoded within mitochondrial DNA. Research links it to AMPK activation, metabolic flexibility, and exercise capacity.
What is MOTS-C?
MOTS-C is a 16-amino-acid peptide encoded within the 12S rRNA region of mitochondrial DNA. It belongs to a class of mitochondrial-derived peptides (MDPs) that includes humanin and the SHLP family.
Unlike most peptides studied in performance research, MOTS-C originates from the mitochondrial genome rather than the nuclear genome, which is part of why it has drawn so much attention in aging and metabolism research.
Mechanism of action
MOTS-C has been shown in cell and rodent models to activate AMP-activated protein kinase (AMPK), the central energy sensor of the cell. Downstream effects in published studies include enhanced glucose uptake, improved insulin sensitivity, and shifts in fatty-acid oxidation.
Additional work has shown MOTS-C translocates to the nucleus under metabolic stress and influences transcription of genes related to antioxidant defense and metabolic adaptation.
Compliance reminder
MOTS-C is sold for laboratory research use only. Not for human consumption, diagnosis, treatment, or cure of any disease.
Frequently asked questions
What is MOTS-C?
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded within mitochondrial DNA. It is one of a small class of mitochondrial-derived peptides studied for metabolic regulation.
What is the mechanism?
Research models suggest MOTS-C activates AMPK, modulates the folate cycle, and influences nuclear gene expression related to metabolic stress response and insulin sensitivity.