HCG Research Guide: LH-Receptor Agonism & Testosterone Research
HCG is a placental glycoprotein hormone that acts as a potent LH-receptor agonist — central to reproductive endocrinology research.
What is HCG?
Human chorionic gonadotropin is produced by syncytiotrophoblast cells of the placenta during pregnancy. Structurally, it is an α/β heterodimer that shares its α-subunit with the three pituitary glycoprotein hormones (LH, FSH, TSH).
Mechanism of action
HCG activates the LH/CG receptor on Leydig cells, mimicking the effects of luteinizing hormone. In male reproductive research, this drives intratesticular testosterone synthesis and supports spermatogenesis. In female research, HCG sustains corpus luteum function and progesterone output.
Sourcing & purity
Research-grade material should be ≥99% pure by HPLC with peptide content confirmed via mass spectrometry. Redline Bio material ships with batch documentation; independent third-party COAs are published on the lab reports page as testing returns.
Compliance reminder
Sold and distributed for laboratory research use only. Not approved by the FDA for human consumption, diagnosis, treatment, or cure of any disease. Researchers are responsible for compliance with all applicable institutional, state, and federal regulations.
Frequently asked questions
What is HCG?
Human chorionic gonadotropin is a 244-amino-acid glycoprotein composed of α (92 aa) and β (145 aa) subunits. The α-subunit is shared with LH, FSH, and TSH; the β-subunit provides receptor specificity.
Mechanism?
HCG binds the LH/CG receptor (LHCGR) on Leydig cells of the testis, stimulating cAMP-mediated steroidogenesis and testosterone production. In females, it maintains corpus luteum function during early pregnancy.