HGH (Somatropin) Research Guide: Mechanism, IGF-1 & Half-Life
Recombinant human growth hormone (Somatropin, 191aa) is the reference molecule for the entire growth-hormone secretagogue space. Here is the research overview.
What is HGH?
Human growth hormone (HGH), generic name Somatropin, is a 191-amino-acid single-chain polypeptide hormone normally produced by the anterior pituitary. The recombinant form used in research is structurally identical to the endogenous molecule.
It is the reference molecule for the entire growth-hormone secretagogue category — every peptide in the GHRH (CJC, Tesamorelin, Sermorelin) and GHRP (Ipamorelin, Hexarelin) families is studied for its ability to elevate endogenous HGH.
Mechanism of action
HGH binds the growth hormone receptor (GHR), a class-I cytokine receptor expressed widely but most densely on hepatocytes. Receptor dimerization activates JAK2 and downstream STAT5 signaling, which transcribes IGF-1.
Hepatic IGF-1 mediates most of HGH's anabolic effects on muscle, bone, and connective tissue. Direct GHR signaling in adipose tissue is also responsible for HGH's lipolytic profile.
Compliance reminder
HGH is sold for laboratory research use only. Not for human consumption, diagnosis, treatment, or cure of any disease.
Frequently asked questions
What is HGH?
HGH (human growth hormone), also called Somatropin, is a 191-amino-acid single-chain protein produced recombinantly to be identical to the endogenous pituitary hormone.
Mechanism?
HGH binds the growth hormone receptor (GHR) on hepatocytes and peripheral tissues, triggering JAK2/STAT5 signaling and hepatic IGF-1 production. Most of its anabolic effects are IGF-1 mediated.